Toxoplasmic Encephalitis in Patient with Acquired Immunodeficiency Syndrome
نویسندگان
چکیده
An epidemic of cases of toxoplasmic encephalitis is occurring in patients with acquired immune deficiency syndrome (AIDS). Serological or histopathologic studies were performed on 70 cases with AIDS and toxoplasmic encephalitis. In many cases conventional stains of brain-tissue specimens failed to disclose Toxoplasma organisms; all were positive when stained by the peroxidase-antiperoxidase technique. Except for a single patient, serological titers were not indicative of an acute acquired infection. The ratio of titers in the agglutination test to titers in the Sabin-Feldman dye test seemed to be more predictive of active toxoplasmic encephalitis in patients with AIDS than either test alone. Based on histological and serological data, an approach is presented for diagnosis and treatment of suspected toxoplasmic encephalitis in patients with AIDS.
منابع مشابه
Drug treatment of toxoplasmic encephalitis in acquired immunodeficiency syndrome.
Toxoplasma gondii is a ubiquitous parasite, which causes several serious diseases. Until the AIDS pandemic, toxoplasmic encephalitis was largely confined to the pharmacologically immune-suppressed and to cases of congenital transmission. T gondii is now one of the more commonly encountered opportunistic pathogens of advanced AIDS.
متن کاملToxoplasmic hepatitis in an immunocompetent patient.
Acquired toxoplasmosis is more frequently an unrecognized disease. Immunocompetent adults and adolescents with primary infection are generally asymptomatic, or symptoms observed may include malaise, fever, and lymphadenopathy. In contrast, immunocompromised patients may experience severe manifestation including encephalitis and multi system organ failure. We report a case of toxoplasmic hepatit...
متن کاملImportance of membrane-bound antigens of Toxoplasma gondii and their fixation for serodiagnosis of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome.
Titers in a direct agglutination test using Formalin-fixed toxoplasma tachyzoites were significantly higher in patients with acquired immunodeficiency syndrome with toxoplasmic encephalitis (TE) than in those without TE. In contrast, when fresh (not fixed) tachyzoites were used, the titers did not differ from those in patients without TE. The direct agglutination test using Formalin-fixed tachy...
متن کاملPrimary Hepatic Burkitt’s Lymphoma in a Patient With Acquired Immunodeficiency Syndrome
Primary non-Hodgkin lymphoma of liver is a very rare malignancy. Here we report a case of primary hepatic Burkitt’s lymphoma in a 34-year old man who was known case of acquired immunodeficiency syndrome (AIDS) and presented with weight loss, abdominal pain, and fever. Positive laboratory findings were mild anemia and elevated levels of lactate dehydrogenase (LDH) and alkaline phosphatase (AL...
متن کاملDiscontinuation of secondary prophylaxis for toxoplasmic encephalitis in human immunodeficiency virus infection after immune restoration with highly active antiretroviral therapy.
Figure 1. A, CT scan before empirical therapy for toxoplasmic encephalitis in an HIV-infected patient. B, CT scan 2.5 years later, after immune restoration with highly active antiretroviral therapy and 8 months without maintenance therapy for toxoplasmic encephalitis. Discontinuation of Secondary Prophylaxis for Toxoplasmic Encephalitis in Human Immunodeficiency Virus Infection After Immune Res...
متن کامل